The giant goiter is enormously a common endocrine abnormality and the interesting phenomenon of enlarged thyroid gland almost exclusively confined to regions of endemic goiter. Goiters can result from biosynthetic defects, iodine deficiency, autoimmune disease or nodular diseases and if left untreated can lead to some symptoms of dyspnea, dysphagia and hoarseness by compressing the trachea, esophagus, and recurrent laryngeal nerve respectively. A majority of patients with giant goiter frequently desire surgical excision for structural distortion (cosmetic) and social reasons. Some of them, however, experience repeated attacks of intercurrent respiratory tract infection which can complicate the postoperative prognosis and cure. About a fifth of giant goiter patients frequently present with acute respiratory distress that requires emergency surgical intervention like tracheostomy. The peri-operative management of this endocrine disease is both formidable and hazardous. The operative time is not merely larger than for a standard thyroidectomy but mortality can also be unacceptably high. Here, we present a case report of a giant euthyroid goiter found in a 70-year-old female patient. The patient underwent fine-needle aspiration cytology examination.